Drug Interactions
Comprehensive guide to drug-drug interactions, pharmacokinetic interactions, and interaction management.
Browse the pages below for detailed information.
clozapine — 5-HT2A receptor Interaction
Drug-target interaction between clozapine and 5-HT2A receptor. Synthetic organic pharmacological agent targeting this protein.
clozapine — D2 receptor Interaction
Drug-target interaction between clozapine and D2 receptor. Synthetic organic pharmacological agent targeting this protein.
cobimetinib — mitogen-activated protein kinase kinase 1 Interaction
Drug-target interaction between cobimetinib and mitogen-activated protein kinase kinase 1. Synthetic organic pharmacological agent targeting this protein.
cobimetinib — mitogen-activated protein kinase kinase 2 Interaction
Drug-target interaction between cobimetinib and mitogen-activated protein kinase kinase 2. Synthetic organic pharmacological agent targeting this protein.
cocaine — DAT Interaction
Drug-target interaction between cocaine and DAT. Natural product pharmacological agent targeting this protein.
codeine — μ receptor Interaction
Drug-target interaction between codeine and μ receptor. Natural product pharmacological agent targeting this protein.
colchicine — tubulin beta class I Interaction
Drug-target interaction between colchicine and tubulin beta class I. Synthetic organic pharmacological agent targeting this protein.
conivaptan — V1A receptor Interaction
Drug-target interaction between conivaptan and V1A receptor. Synthetic organic pharmacological agent targeting this protein.
conivaptan — V2 receptor Interaction
Drug-target interaction between conivaptan and V2 receptor. Synthetic organic pharmacological agent targeting this protein.
corticotropin zinc hydroxide — MC2 receptor Interaction
Drug-target interaction between corticotropin zinc hydroxide and MC2 receptor. Peptide pharmacological agent targeting this protein.
cortisol — Glucocorticoid receptor Interaction
Drug-target interaction between cortisol and Glucocorticoid receptor. Metabolite pharmacological agent targeting this protein.
cosyntropin — MC2 receptor Interaction
Drug-target interaction between cosyntropin and MC2 receptor. Peptide pharmacological agent targeting this protein.
crizotinib — ALK receptor tyrosine kinase Interaction
Drug-target interaction between crizotinib and ALK receptor tyrosine kinase. Synthetic organic pharmacological agent targeting this protein.
crofelemer — CaCC Interaction
Drug-target interaction between crofelemer and CaCC. Natural product pharmacological agent targeting this protein.
crofelemer — CFTR Interaction
Drug-target interaction between crofelemer and CFTR. Natural product pharmacological agent targeting this protein.
cyclizine — H1 receptor Interaction
Drug-target interaction between cyclizine and H1 receptor. Synthetic organic pharmacological agent targeting this protein.
cyclosporin A — peptidylprolyl isomerase A Interaction
Drug-target interaction between cyclosporin A and peptidylprolyl isomerase A. Peptide pharmacological agent targeting this protein.
cyclothiazide — Na-Cl symporter Interaction
Drug-target interaction between cyclothiazide and Na-Cl symporter. Synthetic organic pharmacological agent targeting this protein.
cyproheptadine — H1 receptor Interaction
Drug-target interaction between cyproheptadine and H1 receptor. Synthetic organic pharmacological agent targeting this protein.
cyproterone acetate — Androgen receptor Interaction
Drug-target interaction between cyproterone acetate and Androgen receptor. Synthetic organic pharmacological agent targeting this protein.
Cytochrome P450 Interactions
Cytochrome P450 enzymes are responsible for metabolizing approximately 75% of clinically used drugs. Inhibition or induction of CYP enzymes is a major mechanism of drug-drug interactions.
dabrafenib — B-Raf proto-oncogene, serine/threonine kinase Interaction
Drug-target interaction between dabrafenib and B-Raf proto-oncogene, serine/threonine kinase. Synthetic organic pharmacological agent targeting this protein.
daclizumab — Interleukin-2 receptor subunit α Interaction
Drug-target interaction between daclizumab and Interleukin-2 receptor subunit α. Antibody pharmacological agent targeting this protein.
dalteparin — serpin family C member 1 Interaction
Drug-target interaction between dalteparin and serpin family C member 1. Synthetic organic pharmacological agent targeting this protein.
danaparoid — serpin family C member 1 Interaction
Drug-target interaction between danaparoid and serpin family C member 1. Synthetic organic pharmacological agent targeting this protein.
danazol — Androgen receptor Interaction
Drug-target interaction between danazol and Androgen receptor. Synthetic organic pharmacological agent targeting this protein.
dantrolene — RyR1 Interaction
Drug-target interaction between dantrolene and RyR1. Synthetic organic pharmacological agent targeting this protein.
dapagliflozin — Sodium/glucose cotransporter 2 Interaction
Drug-target interaction between dapagliflozin and Sodium/glucose cotransporter 2. Synthetic organic pharmacological agent targeting this protein.
dapiprazole — α1D-adrenoceptor Interaction
Drug-target interaction between dapiprazole and α1D-adrenoceptor. Synthetic organic pharmacological agent targeting this protein.
dapoxetine — SERT Interaction
Drug-target interaction between dapoxetine and SERT. Synthetic organic pharmacological agent targeting this protein.
daratumumab — CD38 Interaction
Drug-target interaction between daratumumab and CD38. Antibody pharmacological agent targeting this protein.
darifenacin — M3 receptor Interaction
Drug-target interaction between darifenacin and M3 receptor. Synthetic organic pharmacological agent targeting this protein.
darolutamide — Androgen receptor Interaction
Drug-target interaction between darolutamide and Androgen receptor. Synthetic organic pharmacological agent targeting this protein.
dasatinib — ABL proto-oncogene 1, non-receptor tyrosine kinase Interaction
Drug-target interaction between dasatinib and ABL proto-oncogene 1, non-receptor tyrosine kinase. Synthetic organic pharmacological agent targeting this protein.
degarelix — GnRH1 receptor Interaction
Drug-target interaction between degarelix and GnRH1 receptor. Peptide pharmacological agent targeting this protein.
delgocitinib — Janus kinase 1 Interaction
Drug-target interaction between delgocitinib and Janus kinase 1. Synthetic organic pharmacological agent targeting this protein.
delgocitinib — Janus kinase 2 Interaction
Drug-target interaction between delgocitinib and Janus kinase 2. Synthetic organic pharmacological agent targeting this protein.
desipramine — NET Interaction
Drug-target interaction between desipramine and NET. Synthetic organic pharmacological agent targeting this protein.
desipramine — SERT Interaction
Drug-target interaction between desipramine and SERT. Synthetic organic pharmacological agent targeting this protein.
desirudin — coagulation factor II, thrombin Interaction
Drug-target interaction between desirudin and coagulation factor II, thrombin. Peptide pharmacological agent targeting this protein.
deslanoside — sodium/potassium-transporting ATPase subunit α-1 Interaction
Drug-target interaction between deslanoside and sodium/potassium-transporting ATPase subunit α-1. Synthetic organic pharmacological agent targeting this protein.
desloratadine — H1 receptor Interaction
Drug-target interaction between desloratadine and H1 receptor. Synthetic organic pharmacological agent targeting this protein.
desoximetasone — Glucocorticoid receptor Interaction
Drug-target interaction between desoximetasone and Glucocorticoid receptor. Metabolite pharmacological agent targeting this protein.
desvenlafaxine — NET Interaction
Drug-target interaction between desvenlafaxine and NET. Synthetic organic pharmacological agent targeting this protein.
desvenlafaxine — SERT Interaction
Drug-target interaction between desvenlafaxine and SERT. Synthetic organic pharmacological agent targeting this protein.
deucravacitinib — tyrosine kinase 2 Interaction
Drug-target interaction between deucravacitinib and tyrosine kinase 2. Synthetic organic pharmacological agent targeting this protein.
deuruxolitinib — Janus kinase 1 Interaction
Drug-target interaction between deuruxolitinib and Janus kinase 1. Synthetic organic pharmacological agent targeting this protein.
deuruxolitinib — Janus kinase 2 Interaction
Drug-target interaction between deuruxolitinib and Janus kinase 2. Synthetic organic pharmacological agent targeting this protein.
deutenzalutamide — Androgen receptor Interaction
Drug-target interaction between deutenzalutamide and Androgen receptor. Synthetic organic pharmacological agent targeting this protein.
deutetrabenazine — Vesicular monoamine transporter 2 Interaction
Drug-target interaction between deutetrabenazine and Vesicular monoamine transporter 2. Synthetic organic pharmacological agent targeting this protein.
dexamethasone — Glucocorticoid receptor Interaction
Drug-target interaction between dexamethasone and Glucocorticoid receptor. Synthetic organic pharmacological agent targeting this protein.
dexamfetamine — DAT Interaction
Drug-target interaction between dexamfetamine and DAT. Synthetic organic pharmacological agent targeting this protein.
dexamfetamine — NET Interaction
Drug-target interaction between dexamfetamine and NET. Synthetic organic pharmacological agent targeting this protein.
dexetimide — M2 receptor Interaction
Drug-target interaction between dexetimide and M2 receptor. Synthetic organic pharmacological agent targeting this protein.
dexmedetomidine — α2A-adrenoceptor Interaction
Drug-target interaction between dexmedetomidine and α2A-adrenoceptor. Synthetic organic pharmacological agent targeting this protein.
dexmedetomidine — α2B-adrenoceptor Interaction
Drug-target interaction between dexmedetomidine and α2B-adrenoceptor. Synthetic organic pharmacological agent targeting this protein.
dexmedetomidine — α2C-adrenoceptor Interaction
Drug-target interaction between dexmedetomidine and α2C-adrenoceptor. Synthetic organic pharmacological agent targeting this protein.
dexmethylphenidate — DAT Interaction
Drug-target interaction between dexmethylphenidate and DAT. Synthetic organic pharmacological agent targeting this protein.
dextrothyroxine — Thyroid hormone receptor-α Interaction
Drug-target interaction between dextrothyroxine and Thyroid hormone receptor-α. Synthetic organic pharmacological agent targeting this protein.
dextrothyroxine — Thyroid hormone receptor-β Interaction
Drug-target interaction between dextrothyroxine and Thyroid hormone receptor-β. Synthetic organic pharmacological agent targeting this protein.